Oestrogen

Oestrogen

Did you know that oestrogen plays a crucial role in our bodies beyond just reproductive health? This powerful hormone influences various aspects of our well-being, from bone density to mood regulation. Oestrogen, often referred to as the primary female sex hormone, has a significant impact on both men and women, shaping physical characteristics and regulating essential bodily functions.

In this article, we'll explore the world of oestrogen and its many forms, including oestrogen tablets and supplements. We'll discuss the uses of oestrogen medication, how it works in the body, and its potential benefits for women's health. Additionally, we'll examine the importance of maintaining proper oestrogen levels, the effects of imbalances, and how doctors use oestrogen pills for women to address various medical conditions. 

What is Oestrogen?

Oestrogen is a steroid hormone that plays a crucial role in regulating mammalian reproduction. It is primarily known as the female sex hormone but is present in both males and females. The ovaries, adrenal glands, and adipose tissues produce oestrogen. In females, oestrogen prepares the uterus and other reproductive organs for pregnancy. It also regulates the menstrual cycle, stimulates the growth of pubic and underarm hair, and maintains bone strength by working with calcium, vitamin D, and other essential nutrients.

There are three main types of oestrogen: estrone, estradiol, and estriol. Estradiol is the most common type in females during their reproductive years. Estriol levels rise during pregnancy to help the uterus grow and prepare the body for delivery. Oestrogen influences various organs, including the ovaries, vagina, uterus, and breasts. It stimulates the growth of egg follicles, enhances the uterine lining, and contributes to breast tissue formation.

Oestrogen Tablet Uses

Oestrogen tablets serve various medical purposes. Doctors prescribe them primarily to manage menopause symptoms as part of hormone replacement therapy. Oestrogen tablets help alleviate hot flashes, vaginal dryness, and painful intercourse. They also address mood changes, sleep disorders, anxiety, and decreased sexual desire associated with menopause.

Beyond menopause, oestrogen tablets have other important uses: 

• They treat primary ovarian insufficiency and other ovarian issues. 
• Doctors may prescribe them for certain types of acne and some cases of prostate cancer. 
• Oestrogen tablets can help with delayed puberty.
• Oestrogen supplement tablets also play a role in preventing bone loss (osteoporosis) in postmenopausal women. 
• In some cases, doctors use them to treat specific types of breast cancer that have spread to other parts of the body. 
• Women with conditions like hypogonadism or primary ovarian failure may also benefit from oestrogen tablets to supplement their body's natural hormone production.

How to Use Oestrogen Tablets

• Doctors prescribe oestrogen tablets to be taken orally once a day, typically at the same time. 
• Taking the medication exactly as your doctor directs is crucial, without altering the dose or frequency.
• Patients should take the tablets with or without food. Those experiencing nausea can take the tablets with food to alleviate discomfort. 
• For transdermal patches, users should apply them to clean, dry skin on the lower abdomen, hips, or buttocks, avoiding the breasts and waistline. 
• For extended-release tablets, swallowing them whole without crushing, chewing, or dissolving is essential. This ensures proper absorption and medication effectiveness.

Side Effects of Oestrogen Tablets

Oestrogen supplement tablets may cause several common side effects, such as: 

• Stomach upset
• Nausea and vomiting
• Bloating
• Breast tenderness
• Headache
• Weight changes

Some individuals may encounter more severe reactions, including: 

• Mood changes, depression, and mental symptoms, such as memory loss
• Breast lumps
• Unusual vaginal bleeding
• Increased vaginal irritation
• Increased or new vaginal discharge
• Severe abdominal pain
• Swelling of hands, ankles, or feet 
• In rare cases, oestrogen tablets can lead to serious problems from blood clots, like heart attacks or strokes. Patients should seek immediate medical guidance if they experience chest pain, sudden severe headaches, weakness on one side of the body, or trouble speaking. 
• Although rare, a serious allergic reaction may develop, causing symptoms like skin rash, itching, swelling, severe dizziness, or difficulty breathing.

Precautions

• Adherence to Prescribed Dosage: Patients must take oestrogen tablets only as directed by their doctor. They should not exceed the prescribed dose or duration. It's crucial to take the medication at the same time each day to minimise side effects and enhance effectiveness. 
• Allergies: Individuals must inform their doctor about any allergies, medical conditions, or other medications they're taking. 
• Smoking: Smoking while using oestrogen tablets increases the risk of serious side effects. So, avoid it.
• Gynaecological Cancers: Women with unusual vaginal bleeding or a history of certain cancer, such as breast, uterine, or ovary cancer, should exercise caution.
• Medical Conditions: Individuals with certain medical conditions should also inform their doctor before taking this medicine. These may include:
  • Liver disease
  • Kidney disease
  • History of thromboembolism or thrombophlebitis
  • Uterine inconsistency
  • Stroke
  • Blood clotting disorder
  • High cholesterol levels
  • Lupus
  • Hypothyroidism
  • Seizures
  • Migraine
  • Uterus conditions, such as fibroids or endometriosis

How Oestrogen Tablet Works

Oestrogen tablets contain synthetic hormones that mimic the body's natural oestrogen. These tablets enter the bloodstream and bind to oestrogen receptors throughout the body. They impact various organ systems, including the reproductive tract, bones, and brain. The tablets work by supplementing or replacing the body's natural oestrogen production, which declines during menopause or in certain medical conditions. They help regulate the menstrual cycle, maintain bone density, and alleviate symptoms like hot flashes and vaginal dryness. Oestrogen tablets also affect lipid metabolism, increasing high-density lipoproteins (HDL) and decreasing low-density lipoproteins (LDL). This action can reduce the risk of coronary artery disease in postmenopausal women when used early. The tablets' effectiveness relies on their ability to maintain stable hormone levels in the body.

Can I Take Oestrogen with Other Medicines?

Oestrogen tablets can interact with numerous medications, so it's crucial to consult a doctor before combining them. Some products that may interact with oestrogen include: 

• Abacavir
• Abemaciclib
• Aromatase inhibitors
• Fezolinetant
• Fulvestrant
• Levothyroxine
• Ospemifene
• Raloxifene
• Tamoxifen
• Toremifene
• Tranexamic acid

Dosing Information

Oestrogen dosages vary based on the specific condition and individual patient needs. 

• For Postmenopausal Symptoms: Oral doses typically range from 0.5 to 2 mg daily, while transdermal patches deliver 0.025 to 0.1 mg/24 hours. 
• For Atrophic Vaginitis: Vaginal creams, inserts, and rings offer localised treatment. 
• For Hypoestrogenism: Oral doses start at 1 to 2 mg daily, with transdermal options available. 
• Palliative Breast Cancer Treatment: It involves higher oestrogen doses of 10 mg orally thrice daily. 
• For Osteoporosis Prevention: Doses range from 0.5 to 2 mg orally daily. For Prostate cancer palliation: The dose is usually 1 to 2 mg orally thrice daily or 30 mg intramuscular injections every 1-2 weeks. 

Conclusion

Oestrogen's role in our bodies goes far beyond reproductive health, significantly impacting various aspects of our well-being. From regulating bone density to influencing mood, this powerful hormone shapes physical characteristics and essential bodily functions in both men and women. Understanding oestrogen's importance helps us appreciate its effects on overall wellness and the potential benefits of oestrogen-based treatments for various medical conditions.

However, it's crucial to remember that these treatments should always be used under the guidance of a doctor. By maintaining proper oestrogen levels and being aware of potential imbalances, we can take proactive steps to support our health and well-being throughout different stages of life.

FAQ's

1. What does oestrogen do for a woman?

Oestrogen plays a crucial role in female reproductive health and overall well-being. It regulates the menstrual cycle, supports breast development, and maintains vaginal health. This hormone also affects bone density, heart health, and brain function. Oestrogen helps protect against osteoporosis, regulates cholesterol levels, and improves mood stability. During menopause, when oestrogen levels decline, women may experience symptoms like vaginal dryness, hot flashes, and mood changes.

2. What do oestrogen tablets do?

Oestrogen tablets are a form of hormone replacement therapy (HRT) used to address symptoms of menopause and other conditions related to low oestrogen levels. They help alleviate hot flashes, vaginal dryness, and painful intercourse. Oestrogen tablets can also prevent bone loss and diminish the risk of osteoporosis in postmenopausal women. Some formulations combine oestrogen with progestin to reduce the risk of uterine cancer in women who still have their uterus.

3. What are the benefits of taking oestrogen pills?

Taking oestrogen pills can provide relief from menopausal symptoms like hot flashes and vaginal discomfort. They help maintain bone density, reducing the risk of osteoporosis. Oestrogen therapy may also positively affect heart health by improving cholesterol levels and stabilising blood pressure. Some women report improved mood and cognitive function when taking oestrogen pills. Additionally, oestrogen can help maintain skin elasticity and promote better sleep quality.

4. Is it safe for me to take oestrogen pills?

The safety of taking oestrogen pills depends on individual health factors and should be discussed with a doctor. While oestrogen therapy can offer benefits, it also carries potential risks, including an increased chance of stroke, severe headaches, blood clots, and certain types of cancer. The risks may vary based on the dosage and duration of use. Women with a history of certain cancers, liver disease, or blood clots should avoid oestrogen therapy.