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What is Cancer?

Cancer is a condition that happens when normal cells in the body change and grow uncontrollably, forming a tumor. All cancers, except leukemia (blood cancer), follow this pattern. If not treated, tumors can invade surrounding tissue or spread to other parts of the body, either locally or through the bloodstream and lymphatic system, potentially impacting the digestive, nervous, and circulatory systems, or releasing hormones that alter bodily function.

Tumors are classified into benign, malignant, and premalignant. Benign tumors are not cancerous, grow slowly, and don’t spread to other body parts. Malignant tumors are faster growing and have the ability to spread and destroy the neighboring tissue. Premalignant tumors are not cancerous but they can potentially become malignant.

What is cancer

Major Types of Cancer

The cancers can be grouped according to the type of cell growth

Carcinoma

Begins in the skin or in tissues that line or cover internal organs

Sarcoma

Begins in the cells of the immune system

Leukaemia

Begins in the tissues that make blood cells such as the bone marrow

Lymphoma and Myeloma

Begins in the connective or supportive tissues such as bone, cartilage, fat, muscle, or blood vessels.

Brain and spinal cord cancers

These are known as central nervous system cancers and start in the cells of the brain or spinal cord.

Causes of Cancer

Cancers can be caused by various factors, with most being the result of exposure to multiple causes. While some factors cannot be changed, nearly one-third of cancer cases can be prevented by reducing risk from behavior and diet.

Modifiable Risk Factors

Alcohol Consumption

Alcohol is a contributing factor to 6 cancers: colorectal, breast, mouth & throat (pharynx & larynx), oesophageal, liver, and stomach. The risk of cancer increases with higher alcohol consumption and even moderate drinking increases the risk.

Being Overweight or Obese

Being overweight increases the likelihood of developing 12 cancers, including bowel and pancreatic. Cancer risk rises with more weight gain, especially in adulthood.

Diet and Nutrition

A diet high in red and processed meats, and salt, and low in fruits and vegetables increase the risk of cancer. Experts advise that diet and nutrition play a role in cancer risk, especially for colorectum, nasopharynx, and stomach cancers.

Physical Activity

Physical activity reduces not only excess body fat and its related cancer risks, but also lowers the likelihood of colon, breast, and endometrial cancers.

Tobacco

Tobacco smoke has 80+ carcinogens. When inhaled, the chemicals enter the lungs, enter the bloodstream and spread throughout the body, causing not only lung and mouth cancers, but also increasing the risk of many other cancers.

Ionizing and Radiation

Artificial radiation sources can lead to cancer and pose a risk for workers, such as radon, x-rays, gamma rays, and other high-energy radiation. Unprotected prolonged exposure to UV radiation from the sun, sunlamps, and tanning beds can cause melanoma and skin cancers. People with fair skin, many moles, family history of melanoma/skin cancer, are at the highest risk, but skin cancer can occur in all skin tones, including those with darker skin.

Occupational Exposure

Occupational exposure to cancer-causing substances poses a risk for some workers, e.g. higher incidence of bladder cancer among chemical dye industry workers. Asbestos is a widely recognized workplace cause of cancer, particularly mesothelioma, which affects the lung covering.

Infection

Infectious agents cause 2.2 million cancer deaths annually, not through contagiousness but through causing cell changes that increase cancer risk.

Immunosuppressive drugs

Those taking immunosuppressive drugs are likely to develop some types of cancers like Kaposis’s sarcoma.

Non-Modifiable Risk Factors

Age

Cancer incidence increases with age due to prolonged exposure to carcinogens and increased chances of genetic mutations in cells.

Gender

Women are more likely to develop some types of cancers.

Cancer-Causing Substances (Carcinogens)

Carcinogens alter cell behavior and raise cancer risk. Genes contain coded instructions for cell behavior, but mutations or changes to them can cause altered cell behavior and increase the likelihood of cancer.

Genetics

Some people are born with a genetic predisposition to a specific cancer, increasing their likelihood of developing it. For instance, women with the BRCA1 or BRCA2 genes have a higher risk of breast cancer, but less than 5% of all cases are caused by these genes. Similarly, some people have a genetic predisposition for colon cancer, but most cases are not due to inherited genes.

The Immune System

Individuals with weakened immune systems have an increased risk of developing certain cancers. This group includes organ transplant recipients taking immunosuppressive drugs, those with HIV/AIDS and individuals with medical conditions that lower their resistance to disease.

Signs and Symptoms of Cancer

The symptoms of cancers depend and vary based on the type of cancer and location. Here are some key signs and symptoms to look for

Unusual lump/swelling

Changes in bowel habits

Unexplained weight loss

Pain or Ache

Problems related to urination

Appetite Loss

Heartburn or indigestion

Coughing, breathlessness, or difficulty swallowing

Coughing, breathlessness, or difficulty swallowing

Unexpected bleeding

Unexpected bleeding

Fatigue

Fatigue

changes to the mole

New mole or changes to the existing mole

Unusual breast changes

Unusual breast changes

A sore or ulcer

A sore or ulcer that won’t heal

Heavy night sweats

Heavy night sweats

Prevention of Cancer

Nearly one-third of cancers can be prevented by reducing risk factors like tobacco use, obesity, lack of physical activity, infections, alcohol, pollution, workplace carcinogens, and radiation. Vaccination against HBV and HPV can also prevent liver and cervical cancer, respectively. Limiting exposure to other carcinogens can further reduce the risk of cancer.

Early Detection of Cancer

Early detection of some cancers improves treatment outcomes, often with lower costs and fewer side effects. Screening tests for colorectal, breast, cervical, and oral cancers are cost-effective and available, while tests for other cancers are in development. Consult a doctor for guidance on national vaccination, testing, and screening recommendations.

Cancer Staging

Staging cancer by its anatomical extent is crucial for patient care, research, and cancer control. The UICC TNM staging system is widely used by oncologists to communicate the cancer extent. This stage helps determine appropriate treatment and prognosis, informs treatment guidelines, and provides critical information for cancer control and research.

TNM classification focuses on tumor anatomy and considers the following:

T: size of the primary tumor
N: spread to nearby lymph nodes
M: spread to other parts of the body (metastasis).

Treatment Options for Cancer

surgery

Surgery

surgery

Radiotherapy

surgery

Chemotherapy

Immunotherapy

Immunotherapy

Immunotherapy

Hormone therapy

Immunotherapy

Palliative Care

Standing Together for Those Fighting Cancer: World Cancer Day

In a fast-paced digital world, communication happens at lightning speed and nothing should hold us back from supporting and caring for those in need.

This Cancer Day, we want to highlight the importance of coming together as a community to support those who are fighting cancer. We hope this will inspire others to join the movement and help create a world where care is truly a cure.

Facts About Cancer

About CARE Hospitals

CARE Hospitals Group is a multi-Speciality healthcare provider with 17 healthcare facilities serving 7 cities across 6 states in India. A regional leader in South and Central India and counted among the top 5 pan-Indian hospital chains, CARE Hospitals delivers comprehensive care in over 30 medical specialities.